37 research outputs found
Image Performance Characterization of an In-Beam Low-Field Magnetic Resonance Imaging System During Static Proton Beam Irradiation
Image guidance using in-beam real-time magnetic resonance (MR) imaging is expected to improve the targeting accuracy of proton therapy for moving tumors, by reducing treatment margins, detecting interfractional and intrafractional anatomical changes and enabling beam gating. The aim of this study is to quantitatively characterize the static magnetic field and image quality of a 0.22T open MR scanner that has been integrated with a static proton research beamline. The magnetic field and image quality studies are performed using high-precision magnetometry and standardized diagnostic image quality assessment protocols, respectively. The magnetic field homogeneity was found to be typical of the scanner used (98ppm). Operation of the beamline magnets changed the central resonance frequency and magnetic field homogeneity by a maximum of 16Hz and 3ppm, respectively. It was shown that the in-beam MR scanner features sufficient image quality and influences of simultaneous irradiation on the images are restricted to a small sequence-dependent image translation (0.1–0.7mm) and a minor reduction in signal-to-noise ratio (1.3%–5.6%). Nevertheless, specific measures have to be taken to minimize these effects in order to achieve accurate and reproducible imaging which is required for a future clinical application of MR integrated proton therapy
Dosimetric evidence confirms computational model for magnetic field induced dose distortions of therapeutic proton beams
Given the sensitivity of proton therapy to anatomical variations, this cancer
treatment modality is expected to benefit greatly from integration with
magnetic resonance (MR) imaging. One of the obstacles hindering such an
integration are strong magnetic field induced dose distortions. These have been
predicted in simulation studies, but no experimental validation has been
performed so far. Here we show the first measurement of planar distributions of
dose deposited by therapeutic proton pencil beams traversing a one-Tesla
transversal magnetic field while depositing energy in a tissue-like phantom
using film dosimetry. The lateral beam deflection ranges from one millimeter to
one centimeter for 80 to 180 MeV beams. Simulated and measured deflection agree
within one millimeter for all studied energies. These results proof that the
magnetic field induced proton beam deflection is both measurable and accurately
predictable. This demonstrates the feasibility of accurate dose measurement and
hence validates dose predictions for the framework of MR-integrated proton
therapy
Comment on 'Comparative evaluation of two dose optimization methods for image-guided, highly-conformal, tandem and ovoids cervix brachytherapy planning'
Comparison of optimization algorithms for inverse treatment planning requires
objective function value evaluation
Image Performance Characterization of an In-Beam Low-Field Magnetic Resonance Imaging System During Static Proton Beam Irradiation
Image guidance using in-beam real-time magnetic resonance (MR) imaging is expected to improve the targeting accuracy of proton therapy for moving tumors, by reducing treatment margins, detecting interfractional and intrafractional anatomical changes and enabling beam gating. The aim of this study is to quantitatively characterize the static magnetic field and image quality of a 0.22T open MR scanner that has been integrated with a static proton research beamline. The magnetic field and image quality studies are performed using high-precision magnetometry and standardized diagnostic image quality assessment protocols, respectively. The magnetic field homogeneity was found to be typical of the scanner used (98ppm). Operation of the beamline magnets changed the central resonance frequency and magnetic field homogeneity by a maximum of 16Hz and 3ppm, respectively. It was shown that the in-beam MR scanner features sufficient image quality and influences of simultaneous irradiation on the images are restricted to a small sequence-dependent image translation (0.1–0.7mm) and a minor reduction in signal-to-noise ratio (1.3%–5.6%). Nevertheless, specific measures have to be taken to minimize these effects in order to achieve accurate and reproducible imaging which is required for a future clinical application of MR integrated proton therapy
Image Performance Characterization of an In-Beam Low-Field Magnetic Resonance Imaging System During Static Proton Beam Irradiation
Image guidance using in-beam real-time magnetic resonance (MR) imaging is expected to improve the targeting accuracy of proton therapy for moving tumors, by reducing treatment margins, detecting interfractional and intrafractional anatomical changes and enabling beam gating. The aim of this study is to quantitatively characterize the static magnetic field and image quality of a 0.22T open MR scanner that has been integrated with a static proton research beamline. The magnetic field and image quality studies are performed using high-precision magnetometry and standardized diagnostic image quality assessment protocols, respectively. The magnetic field homogeneity was found to be typical of the scanner used (98ppm). Operation of the beamline magnets changed the central resonance frequency and magnetic field homogeneity by a maximum of 16Hz and 3ppm, respectively. It was shown that the in-beam MR scanner features sufficient image quality and influences of simultaneous irradiation on the images are restricted to a small sequence-dependent image translation (0.1–0.7mm) and a minor reduction in signal-to-noise ratio (1.3%–5.6%). Nevertheless, specific measures have to be taken to minimize these effects in order to achieve accurate and reproducible imaging which is required for a future clinical application of MR integrated proton therapy
Balancing radiation pneumonitis versus locoregional tumor control in non-small-cell lung cancer
Item does not contain fulltex